{"id":19900,"date":"2025-04-19T09:51:45","date_gmt":"2025-04-19T00:51:45","guid":{"rendered":"http:\/\/journal.shinealight.jp\/?p=19900"},"modified":"2025-04-19T10:15:13","modified_gmt":"2025-04-19T01:15:13","slug":"%e7%88%b6%e3%81%ae%e6%ad%bb%e3%81%8b%e3%82%89%e8%80%83%e3%81%88%e3%82%8b%e3%80%81%e7%b2%be%e5%af%86%e6%a0%84%e9%a4%8a%e5%ad%a6%e3%81%ae%e5%8f%af%e8%83%bd%e6%80%a7","status":"publish","type":"post","link":"https:\/\/journal.shinealight.jp\/?p=19900","title":{"rendered":"\u7236\u306e\u6b7b\u304b\u3089\u8003\u3048\u308b\u3001\u7cbe\u5bc6\u6804\u990a\u5b66\u306e\u53ef\u80fd\u6027"},"content":{"rendered":"\n<p>\u50d5\u306e\u7236\u306f\u3001ALS\uff08\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff09\u3067\u4ea1\u304f\u306a\u3063\u305f\u3002\u3082\u304613\u5e74\u306b\u306a\u308b\u3060\u308d\u3046\u304b\u2026<\/p>\n\n\n\n<p>\u3086\u3063\u304f\u308a\u3068\u624b\u8db3\u304c\u52d5\u304b\u306a\u304f\u306a\u308a\u3001\u8a00\u8449\u304c\u8a71\u3057\u3065\u3089\u304f\u306a\u308a\u3001\u3084\u304c\u3066\u547c\u5438\u304c\u3067\u304d\u306a\u304f\u306a\u3063\u3066\u3044\u304f\u3002 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class=\"wp-block-list\">\n<li>\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306b\u3088\u308b\u8208\u596e\u6bd2\u6027<\/li>\n\n\n\n<li>TDP-43\u3084FUS\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7570\u5e38\u51dd\u96c6<\/li>\n\n\n\n<li>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u5927<\/li>\n\n\n\n<li>\u6162\u6027\u708e\u75c7\u304a\u3088\u3073\u514d\u75ab\u53cd\u5fdc\u306e\u7570\u5e38<\/li>\n\n\n\n<li>\u5bb6\u65cf\u6027\u306e\u5834\u5408\u306fSOD1\u3084C9orf72\u306a\u3069\u306e\u907a\u4f1d\u5b50\u5909\u7570<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3044\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3001\u6700\u7d42\u7684\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u7d30\u80de\u6b7b\uff09\u306b\u81f3\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 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class=\"wp-block-list\">\n<li>\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u306e\u5f31\u5316<\/li>\n\n\n\n<li>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u6162\u6027\u7684\u306a\u708e\u75c7\u72b6\u614b<\/li>\n\n\n\n<li>\u6709\u5bb3\u91d1\u5c5e\u3084\u6bd2\u7d20\u306e\u84c4\u7a4d<\/li>\n\n\n\n<li>\u5fc5\u9808\u6804\u990a\u7d20\u306e\u9577\u671f\u7684\u306a\u4e0d\u8db3<\/li>\n<\/ul>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001ALS\u60a3\u8005\u306e\u8133\u810a\u9ac4\u6db2\u4e2d\u306b\u304a\u3051\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306e\u904e\u5270\u3084\u3001TDP-43\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7570\u5e38\u84c4\u7a4d\u3001 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u640d\u50b7\u3001\u7d30\u80de\u5185\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u6307\u6a19\u306e\u4e0a\u6607\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001 \u75c5\u6c17\u306e\u80cc\u666f\u306b\u3042\u308b&#8221;\u898b\u3048\u306a\u3044\u4ee3\u8b1d\u7684\u306a\u8106\u5f31\u6027&#8221;\u304c\u3001\u78ba\u5b9f\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7cbe\u5bc6\u6804\u990a\u5b66\u304c\u6559\u3048\u3066\u304f\u308c\u308b\u3082\u306e<\/h2>\n\n\n\n<p>ALS\u306e\u3088\u3046\u306a\u795e\u7d4c\u75be\u60a3\u3092\u542b\u3081\u3001\u6162\u6027\u75c5\u3084\u539f\u56e0\u4e0d\u660e\u306e\u4e0d\u8abf\u306b\u306f\u5171\u901a\u70b9\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<ul 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class=\"has-fixed-layout\"><thead><tr><th>\u898b\u3048\u306a\u3044\u3082\u306e<\/th><th>\u7cbe\u5bc6\u6804\u990a\u5b66\u3067\u306e\u53ef\u8996\u5316\u624b\u6bb5<\/th><\/tr><\/thead><tbody><tr><td>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5143\u6c17\u3055<\/td><td>\u4e73\u9178\uff0f\u30d4\u30eb\u30d3\u30f3\u9178\u6bd4\u3001CoQ10\u30ec\u30d9\u30eb\u3001ATP\u4ee3\u8b1d\u6307\u6a19<\/td><\/tr><tr><td>\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/td><td>8-OHdG\u3001MDA\u3001SOD\u6d3b\u6027\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u6bd4<\/td><\/tr><tr><td>\u89e3\u6bd2\u80fd\u529b<\/td><td>\u809d\u6a5f\u80fd\uff0b\u30d5\u30a7\u30fc\u30ba1\/2\u89e3\u6bd2\u9175\u7d20\u3001\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u72b6\u614b<\/td><\/tr><tr><td>\u795e\u7d4c\u306e\u6804\u990a\u72b6\u614b<\/td><td>\u30d3\u30bf\u30df\u30f3B\u7fa4\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u3001\u30bb\u30ea\u30f3\u30fb\u30b0\u30ea\u30b7\u30f3\u30fb\u30bf\u30a6\u30ea\u30f3\u6fc3\u5ea6<\/td><\/tr><tr><td>\u708e\u75c7<\/td><td>hs-CRP\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6, 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